Research Associate, Genome Engineering at Colossal Biosciences

Colossal is seeking a Research Associate to support genome engineering projects in mammalian systems by performing core molecular biology workflows, including plasmid preparation, PCR, gel electrophoresis, and DNA quality control. This role will also assist with routine lab operations in support of the Thylacine team. Working closely with senior team members, the Research Associate will contribute to Colossal’s mission of advancing genome engineering technologies for de-extinction and conservation. 

This position is based on-site in Dallas, TX. Relocation assistance is available. 

Duties and Responsibilities:

• Work with senior lab members to support the design, development, and testing of multiplex genome engineering tools in mammalian cells
• Perform routine molecular biology workflows, including plasmid DNA preparation (mini/midi/maxi preps), PCR, gel electrophoresis, and gel analysis
• Assist with general lab operations, such as inventory management, preparation of common stocks, and basic equipment maintenance
• Work on project milestones, attend team meetings, prepare progress reports, and presentations

Required Skills and Abilities

• Ability to thrive in a fast-paced environment
• Strong written and oral communication skills, as well as creative problem-solving skills
• Great organizational skills and excellent laboratory record maintenance
• Proficiency in aseptic technique for E. coli culture and handling
• Hands-on experience with core molecular biology techniques, including plasmid DNA preparation (mini/midi/maxi preps), genomic DNA preparation, PCR, gel electrophoresis, and DNA quality control
• Familiarity with sequence analysis software (e.g., SnapGene, Geneious)

Preferred Skills and Abilities

• Experience with RNA extraction, RNA handling, and qPCR methods
• Familiarity with electronic lab notebooks (ELN) and laboratory inventory management systems
• Prior experience with cloning techniques (restriction enzyme–based cloning, Gibson assembly, or similar methods)

Education and Experience:

• Bachelors in biological sciences, bioengineering, molecular biology, genetics, or any science related field
• Previous experience as a Research Associate or technician in an academic or biotechnology industry setting is a plus

What We Value

Colossal’s Genome Engineering team emphasizes collaboration, transparency, and mutual support. We are committed to maintaining a culture where every team member — from Research Associate to Scientist — contributes meaningfully to scientific progress, while respecting the importance of shared responsibility and collective success.