Lead Scientist, Discovery Biology
About GondolaBio
GondolaBio is a clinical-stage biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Originally launched as BridgeBioX, a subsidiary of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. The company aims to leverage cutting-edge biological research to create breakthrough medicines addressing high unmet needs across multiple therapeutic areas, including neurology, pulmonology, cardiology, nephrology, and endocrinology. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation.
Who you are
We are seeking a highly motivated Scientist to join our Discovery Biology team and drive translational biomarker strategy in one of our renal programs.
This individual will play a key role in developing, validating, and implementing biomarker assays to support clinical trials, with a focus on renal physiology and related disease areas. The ideal candidate will combine strong technical expertise in biomarker sciences with experience bridging preclinical and clinical research in a regulated environment.
Requirements
Key Responsibilities
- Design and execute in vitro and in vivo studies to identify and validate novel biomarkers and elucidate mechanisms of action for GondolaBio’s therapeutic candidates.
- Develop, optimize, and validate biomarker assays (molecular, cellular, immunological) using mouse and human-derived samples to support translational research.
- Provide scientific and technical leadership in various biomarker platforms and evaluate emerging biomarker technologies for clinical relevance and technical performance; integrate innovative approaches into ongoing programs.
- Analyze and interpret biomarker data from preclinical and clinical studies; communicate findings clearly to cross-functional teams.
- Implement biomarker plans in clinical protocols and lab manuals; oversee assay execution at CROs and external partners under Good Clinical Practice (GCP).
- Partner effectively with internal and external stakeholders and maintain well-documented research records.
Education, Experience, & Skills Requirements
- Ph.D. in Molecular/Cell Biology, Immunology, or a related discipline with 2+ years of relevant industry experience, or B.S./M.S. with 5+ years of industry experience.
- Strong expertise in utilizing in vitro experimental techniques as they pertain to a biomarker strategy, including:
- Flow cytometry
- Ligand binding assays
- ELISA, MSD, Simple Western automated Western blot systems
- Primary cell culture and functional in vitro assays
- RNA isolation/sequencing, qPCR/ddPCR
- Immunohistochemistry (IHC), ISH, multiplex immunofluorescence
- Demonstrated ability to rigorously analyze, interpret, and present complex datasets.
- Strong problem-solving, communication, and cross-functional collaboration skills.
Preferred Skills (a plus):
- Proficiency with high-dimensional data analysis for gene expression, WGS, cfDNA, or proteomics datasets.
- Experience with advanced technologies such as mass spectrometry, PEAs, automated IHC (e.g., Leica Bond), and Incucyte live-cell imaging.
- Experience working with contract research organizations and third-party labs.
No matter your role at GondolaBio, successful team members are:
- Patient Champions, who put patients first and uphold strict ethical standards
- Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
- Truth Seekers, who are detailed, rational, and humble problem solvers
- Individuals Who Inspire Excellence in themselves and those around them
- High-quality executors, who execute against goals and milestones with quality, precision, and speed
What We Offer
- Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
- A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
- An unyielding commitment to always putting patients first.
- A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
- A place where you own the vision – both for your program and your own career path
- A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
- Access to learning and development resources to help you get in the best professional shape of your life
- Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
- Flexible PTO
- Rapid career advancement for strong performers
- Potential ability to work on multiple GondolaBio Pharma programs across multiple therapeutic areas over time
- Partnerships with leading institutions
- Commitment to Diversity, Equity & Inclusion
The base pay range for this position is $150,000 to $200,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.
