Sr. Scientist of Study Operations, Pharmacology (Contract) at Centessa Pharmaceuticals, LLC

Description of Role

The (contract) Senior Scientist for Study Operations, Pharmacology will oversee day-to-day operations of in vitro and in vivo pharmacology studies conducted remotely at specialized CRO’s including study forecasting, budgeting, planning, execution, data management, quality assurance, communications, and collaboration across a portfolio of Orexin agonist programs. This role requires a strong background in pharmacology, a high degree of accuracy and attention to detail, and the ability to identify and resolve issues that arise during study execution. It will support pharmacology activities that are conducted in a matrix fashion to support all research and clinical development programs.

Key Responsibilities

• Coordinate outsourcing with responsibility for planning, execution, and oversight of pharmacology studies, ensuring robust methodology and alignment with program goals
  • Oversee multiple parallel in vitro screening efforts to ensure efficient and timely progression of compounds through GPCR functional and binding assays
  • Coordinate with internal teams and CRO partners to guide study execution, troubleshoot issues, and uphold scientific and operational rigor
  • Manage end-to-end data flow between external CROs and internal teams—from assay/study initiation through analysis and reporting—ensuring accuracy, consistency, and alignment with study objectives
• ordinate internal review and approval of CRO study contracts and track to full execution to ensure timely study initiation at the CRO
  • Initiate and manage multiple in vitro and in vivo study agreements in collaboration with legal and finance, and coordinate compound shipments with CMC.
  • Coordinate finalization of protocols for pharmacology studies, working with DMPK, bioanalytical, and CMC team members
• Attend project meetings to stay informed and expedite studies as needed, and provide updates to project teams upon request
• Track study deliverables and communicate study progress to relevant team members and management; maintain an integrated calendar to track in vitro assay set-up, in progress screening, and downtime, forecasting pharmacology study deliverables across the entire portfolio for efficient planning of resources; Gantt chart for planned and ongoing in vivo studies

Education and Qualifications:

• • Advanced degree (bachelor's or above) in pharmacology or related scientific field.
  • 8+ years of pharmacology experience in a contract research laboratory, pharmaceutical, or biotechnology company
  • Strong understanding of pharmacology, biological sciences, and nonclinical research methodologies
  • Demonstrated competency with one or more of the following techniques: Radioligand binding, FLIPR calcium mobilization, cyclic AMP (cAMP) accumulation, inositol phosphate (IP) turnover, arrestin (beta-arrestin/beta-arrestin recruitment)
  • Highly organized, with proven ability to manage multiple simultaneous pharmacology studies, timelines, and data deliverables
  • Proficient in scientific data analysis software packages, databases, and data management systems, with the ability to quickly learn and adapt to new software tools
  • Must have excellent oral and written communication, active listening, negotiation, and interpersonal relationship skills
  • Contract Duration: 6-9 months
  • Work Authorization : Green Card, US Citizen
  • Travel Required : No travel required