Research Fellow - Gastroenterology and Hepatology bei Mayo Clinic
Mayo Clinic · Rochester, Vereinigte Staaten Von Amerika · Onsite
- Professional
- Optionales Büro in Rochester
Postdoctoral Research Fellow - Translational Mucosal Immunology
Primary Focus
Lead bench-based translational studies in the Kattah Lab (Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN) using patient intestinal biopsies and blood to dissect mechanisms of inflammatory bowel disease, CAR-T enteritis, and ICI colitis. Integrate single-cell/spatial multi-omics with experimental validation in human/mouse intestinal organoids and co-culture systems.
Key Responsibilities & Activities
Process patient biopsies/PBMCs, generate single-cell datasets (scRNA/CITE-seq), and identify testable pathways.
Validate targets in tissue using immunofluorescence/spatial transcriptomics and in vitro using organoid-immune and organoid-stromal co-cultures.
Perform CRISPR-Cas9 perturbations and functional epithelial assays (barrier integrity, viability, cytokine readouts), and imaging/flow cytometry.
Maintain rigorous records, QC, and SOP adherence for human biospecimens.
Analyze/interpret data with basic scripting skills (R/Python) and collaborate closely with computational partners.
Write manuscripts, prepare figures, and present at lab/departmental meetings and national/international conferences
Help mentor students/technicians.
(~70% wet-lab experimentation, ~20% data analysis/interpretation, ~10% writing/mentoring.)
Qualifications
PhD in Immunology, Molecular/Cell Biology, Cancer Biology, Developmental Biology, Genetics/Genomics, Biochemistry, Microbiology, Pharmacology, Bioengineering/Biomedical Engineering, Neuroscience, or closely related field.
Substantial wet-lab experience: sterile cell culture, flow cytometry, mouse models of disease.
Strong communication skills and at least one 1 peer-reviewed publication.
Preferred qualifications
Experience with intestinal organoids
Hands-on CRISPR editing/perturbation screens, including assay development and troubleshooting.
Familiarity with single-cell/spatial pipelines and basic informatics (R or Python).
About Company
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.
Company
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
- Medical: Multiple plan options.
- Dental: Delta Dental or reimbursement account for flexible coverage.
- Vision: Affordable plan with national network.
- Pre-Tax Savings: HSA and FSAs for eligible expenses.
- Retirement: Competitive retirement package to secure your future.
