Senior Scientist, in vivo Pharmacology bei Stoke Therapeutics
Stoke Therapeutics · Bedford, Vereinigte Staaten Von Amerika · Onsite
- Senior
- Optionales Büro in Bedford
About Stoke:
Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights
Stoke’s initial focus for its TANGO platform is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency).
Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.
Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach.
Position Purpose:
The Senior Scientist will work collaboratively across the Research organization to support preclinical efforts in understanding the target engagement, pharmacology, and efficacy of novel compounds in disease models. This position requires a scientist with experience designing and executing thoughtful in vivo studies and developing assays to establish and investigate preclinical biomarkers in tissue samples. This position will report into the Executive Director of in vivo pharmacology.
Key Responsibilities:
- Support the in vivo characterization of novel compounds by designing and overseeing in life studies and performing molecular analysis with a combination of internal and outsourced resources.
- Work collaboratively across functions to support programs through preclinical proof of concept and candidate selection to advance the company pipeline.
- Use a high level of scientific judgment to adapt and/or create standard methods and techniques by applying breadth of knowledge and prior work experience.
- Develop and optimize preclinical biomarker assays to support discovery efforts and bridge into early development activities.
- Maintain excellent and timely recordkeeping while adhering to aggressive timelines
- Author study reports that may be used for regulatory filings and scientific manuscripts.
Required Skills & Experience:
- Bachelor’s degree with 16+ years of experience, or Master’s degree with 10+ years of post-graduate experience, or Ph.D. with 6+ (industry experience is a plus). Degrees in Pharmacology, Neuroscience or relevant disciplines highly preferred.
- Experience working in drug discovery with an emphasis on neurology indications, experience working with oligonucleotides is a plus.
- Designing and managing experiments at contract research organizations.
- Experience developing and optimizing assays in tissue matrix (i.e MSD, ELISA, qPCR), IHC skills a plus.
- Excellent verbal and written communication skills.
- Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.
Location(s):
Stoke operates in Bedford, MA. This position is onsite with an office based in Bedford, MA.
Travel:
This position will require approximately 5% travel.
Culture & Values:
At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.
Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do.
Benefits & Compensation:
At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.
Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center.
For more information, visit stoketherapeutics.com or follow the company on X at @StokeTx.
All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.
Stoke participates in E-Verify.
