Senior Director, Clinical Genomics Laboratory (London, GB, SW1H 0DB) bei BioNTech

London, United Kingdom   |   full time   |   Job ID: 9739 

 

 

BioNTech is establishing a cutting-edge genomics hub in Cambridge, UK, to support our clinical studies and advance genomics approaches for our individualized mRNA cancer vaccine platforms. As part of this initiative, we are building substantial next-generation sequencing (NGS) capacities in Cambridge to support our clinical trials and individualized mRNA cancer vaccine manufacture via diagnostic applications and neoantigen discovery. 

We are seeking an experienced and visionary Site Head to lead and oversee the operations of a GxP-compliant genomics laboratory specializing in Illumina sequencing technology for whole exome sequencing (WES) and RNA sequencing (RNA-Seq).  

 

In this role, you will own the end-to-end management of the genomics workflow, ensuring seamless execution and impactful results. With your expertise in technology transfer, instrument qualification, analytical method validation, and laboratory information management systems (LIMS), you will set the standard for operational excellence and regulatory compliance.

 

Your mission: Deliver high-quality genomic data that propels precision medicine and translational research forward. This role further offers a unique opportunity to build a state-of-the-art clinical research site from the ground up and to shape the future of individualized cancer therapies.

 

As the leader of a multidisciplinary team of NGS experts, technology developers, and researchers, you will foster collaboration across the UK clinical genomics network, driving progress and innovation.

 

Your main responsibilities are: 

 

Leadership and Strategy

 

• Develop and execute the strategic vision for the genomics laboratory, ensuring alignment with organizational goals and clinical trial timelines.
• Lead the implementation and optimization of Illumina sequencing workflows for WES and RNA-Seq, focusing on diagnostic applications and neoantigen discovery
• Drive innovation in laboratory processes while maintaining compliance with GCLP standards and regulatory requirements
• Foster a culture of scientific excellence, collaboration, and continuous improvement within the laboratory team

 

Operational Management

 

• Oversee the end-to-end genomic workflow, including sample reception, Histology, Blood Processing, Nucleic Acid Extraction, NGS Library Preparation, and Sequencing
• Manage laboratory resources, including personnel, equipment, consumables, and reagents, to ensure operational efficiency and scalability
• Develop and monitor key performance indicators (KPIs) to track laboratory performance and identify areas for improvement

 

Regulatory Compliance and Quality Assurance

 

• Ensure all laboratory processes comply with GCP for labs, CLIA, CAP, and other relevant regulatory standards
• Lead instrument qualification, analytical method validation, and technology transfer activities to ensure robust and reproducible workflows
• Collaborate with the Quality Assurance (QA) team to implement and maintain a comprehensive quality management system (QMS)
• Prepare for and lead audits and inspections, addressing findings and implementing corrective actions as needed

 

Scientific and Technical Expertise

 

• Provide scientific oversight for Illumina sequencing workflows, including optimization of protocols for WES and RNA-Seq applications
• Collaborate with bioinformatics teams to refine pipelines for neoantigen discovery and diagnostic applications
• Integrate advancements in sequencing technologies and ensure validation for clinical trial standards

 

Technology Transfer and Instrument Qualification

 

• Lead technology transfer activities for new workflows, ensuring seamless integration into laboratory operations.
  LIMS
• Manage and optimize Laboratory Information Management Systems (LIMS) to ensure seamless sample tracking, workflow efficiency, data integrity, and integration with downstream analysis and reporting pipelines 

 

Collaboration and Stakeholder Engagement

 

• Serve as the main point of contact for internal teams and external stakeholders, including clinical trial sponsors, regulatory agencies, and collaborators, ensuring laboratory work aligns with project goals through coordination with clinical, bioinformatics, and research teams
• Represent the laboratory at scientific conferences, industry meetings, and client presentations

 

 What you have to offer:

 

Education

 

• PhD or equivalent advanced degree in Genomics, Molecular Biology, or a related field

 

Experience

 

• Minimum of 8-10 years of experience in genomics, molecular diagnostics, or clinical laboratory operations, with at least 3-5 years in a leadership role
• Proven expertise in Illumina sequencing technology, including WES and RNA-Seq workflows
• Extensive experience in technology transfer, instrument qualification, analytical method validation, and LIMS implementation
• Demonstrated ability to manage compliant laboratories and support clinical trials
• In-depth knowledge of regulatory standards (e.g., GCP for labs, CLIA, CAP) and quality management systems

 

Skills

 

• Strong leadership and team management skills, with the ability to inspire and motivate multidisciplinary teams
• Excellent problem-solving and decision-making abilities in a fast-paced, high-stakes environment
• Exceptional communication and interpersonal skills, with the ability to build relationships with diverse stakeholders

 

 

Your Benefits:

 

BioNTech is committed to the wellbeing of our team members and offers a variety of benefits in support of our diverse employee base. We offer competitive remuneration packages which is determined by the specific role, location of employment and also the selected candidate’s qualifications and experience.

 

Note: The availability, eligibility and design of the listed benefits may vary depending on the location. The final requirements for the individual use of our benefits are based on the company's internal policies and applicable law.

 

How to apply:

 

Apply now by sending us your application documents including Curriculum Vitae, copy of ID, copies of degree certificates and professional certificates, motivation letter as well as your contact details via our online form.

 

Please note:

Only applications sent via our online form shall be considered. By submitting your application, you acknowledge that a background check will be conducted as part of the recruitment process in accordance with applicable laws and regulations. If you are considered for the position, BioNTech will conduct the background check through our service provider ‘HireRight’. You will be informed accordingly by your BioNTech-Recruiter.

 

We are looking forward receiving your application.

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