Assistant Scientist bei The Morgridge Institute for Research

Description

We are seeking a highly motivated scientist with published experience in animal research, imaging, and/or histological techniques, with an exceptional background in molecular biology. The Poss lab utilizes zebrafish and, occasionally, mice as model systems to study regeneration of appendages, heart muscle, spinal cord, and other organ systems. The Assistant Scientist will support regenerative biology research objectives by conducting research on molecular genetics of tissue regeneration. They will be asked to work independently and with others to develop tools and genetically modified animals, as well as other related experiments. They will prepare materials to be used in grants and manuscripts and assist in the training of personnel in complex methods. 

Primary Responsibilities:

• Independently design, implement and conduct experiments under the supervision of the Principal Investigator
• Generate and use DNA- and RNA-based tools to genetically manipulate zebrafish. The candidate should be able to generate and organize many genetic lines of animals for experimentation.
• Generate constructs for preparation of antigens for antibody generation, and recombinant AAV vectors.
• Provide experimental assistance with projects driven by other lab members as directed to support the mission and objectives of the Poss lab
• Collect research data through research tool generation, observation, experimentation and various other methods, to include operating technical laboratory instruments and equipment, for presentation in papers, talks, and grant applications.
• Perform technical procedures with research animals; maintain records and write reports in accordance with general laboratory animal procedures and in compliance with required regulations.
• Prepare tissue and specimens for complex procedures in tissue regeneration and devise experimental techniques for tests and analyses. Evaluate and interpret collected data and prepare reports and analyses setting forth progress, adverse trends and appropriate recommendations or conclusions.
• Supervise, train and instruct students or less experienced personnel in laboratory techniques and procedures.
• Read journals, abstracts and scientific literature to keep abreast of new developments and to obtain information regarding previous experiments to aid in the design and development of original procedures and techniques. 
• Perform other related duties incidental to the work described herein.

Requirements

To perform this job successfully, an individual must be able to perform each primary duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the primary duties.

Education and Experience:

· PhD in biology or related field

· A minimum of 5 years of postdoctoral training required 

· Successful experience with techniques and approaches relevant to regenerative biology

· Previous animal handling experience 

Knowledge, Skills and Abilities Required:

· Experience with experiments using research animals

· Strong background in biology or engineering

· Co-authored contributions to primary research reports

· Exceptional expertise in molecular biology 

· Ability to perform reproducible imaging experiments

· Must have the ability to work both independently and part of a dynamic research team

· Strong written and oral communication skills are essential

Working Conditions and Physical Effort:

· Standing for long periods of time is required

· Work is normally performed in a wet laboratory environment

· No or very limited physical effort is required

· No or very limited exposure to physical risk

· Occasional evening and weekend work expected