Scientist bei Marea Therapeutics Inc

Description

Marea Therapeutics is a clinical-stage biotechnology company based in San Francisco with a growing pipeline of first-in-class therapies to address genetically validated cardioendocrine disease targets. Our therapies have the potential to complement existing therapies and serve as transformative treatment options for significant patient populations living with cardioendocrine diseases. 

Incubated by Third Rock Ventures, Marea completed a Series B financing in June 2024 and is now well funded by a syndicate of life science investors including Sofinnova, Forbion, Perceptive Advisors, Xontogeny, venBio, Omega Funds, Surveyor, Alpha Wave and Third Rock Ventures.  The company’s lead program is in Phase 2 clinical development (MAR001) and a MAR002 is progressing towards clinical development acromegaly[MC1] .  Marea is a fast-growing company looking for extraordinary individuals to join our team who want to make a difference in the lives of millions of people living with cardioendocrine diseases. The company is led by a dynamic team of scientists and company builders with deep knowledge and experience in cardioendocrine diseases, human genetics, and adipocyte biology.  

At Marea, we believe in the power of collaboration and the importance of leading by example. We are a tight-knit team that values the contributions of every member, from interns to senior leaders. Our environment is dynamic, with each day presenting new challenges and opportunities for growth. Every role is “Hands-On”, and the successful candidate will be able to work alongside team members, regardless of level, to understand challenges and drive results. 

ABOUT THE ROLE

We are seeking a highly motivated Scientist with broad hands-on experience with in vitro  molecular/cell-based assays and antibody functional characterization studies to join our research team. This role will work closely with the head of biology and other research team members in the optimization and execution of molecular, cellular and ex vivo studies to support drug candidate selection and preclinical research. A good foundation in cell culture, tissue and blood sample processing, functional bioassays and gene expression assays is essential. The ideal candidate will have technical excellence, scientific rigor, great interpersonal/collaboration skills and outstanding work ethic.

This is a full-time, San Francisco-based position with the expectation of working on-site.

Requirements

Cell and tissue culture and processing
Execute workflows involving mammalian cell culture (including primary cells), as well as processing of solid tissues and blood samples (e.g., PBMCs, serum, plasma). Prepare lysate samples or isolate DNA/RNA for downstream molecular analysis.

High-throughput (96-/384-well) molecular biology and immune-based quantitative assays

Branched DNA assay, RT-qPCR, ELISA, Western blot and other immunoassays to evaluate mRNA and protein levels in a variety of biological matrices.

Antibody characterization assays

Optimization and execution of in vitro/cell-based assays for functional evaluation of antibody activity.

Scientific communication
Keep impeccable experiment and data records. Present results clearly to internal teams; contribute data to scientific publications, regulatory documents, and conference materials.

QUALIFICATIONS:

• B.S./M.S. in Life Sciences (e.g., Molecular Biology, Cell Biology, Biochemistry, Physiology) with 8+ years of applied biology industry experience.
• Strong knowledge of cell culture techniques.
• Skilled in cell, tissue and blood sample processing.
• Hands-on experience with high-throughput quantitative in vitro assays.
• Familiar with assay qualification principles and best practices in biological variability and required assay controls.
• Ability to work both independently and in a collaborative way. We are a lean team, and you may be required to cover for planned absences of other team members.
• Experience with biological data analysis software (e.g., GraphPad Prism, SoftMax Pro,FlowJo, etc.) and ELN.
• Comfortable working in the fast-paced environment of biotech start-up 
• Experience supporting/contributing to drug discovery, drug candidate selection, or IND-enabling studies preferred

WORKING CONDITIONS 

• Prolonged periods of seating and standing and working in a laboratory environment 
• Ability to occasionally adjust, handle, or move objects up to 50 pounds