Associate Scientist, in vivo Pharmacology bei Stoke Therapeutics
Stoke Therapeutics · Bedford, Vereinigte Staaten Von Amerika · Onsite
- Senior
- Optionales Büro in Bedford
About Stoke:
Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights
Stoke’s initial focus for its TANGO platform is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency).
Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.
Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach.
Position Purpose:
Stoke is seeking an enthusiastic and highly motivated Senior Research Associate to join the In Vivo Pharmacology Department. This position is an opportunity to learn new techniques and concepts, be creative, and grow with a growing company.
Key Responsibilities:
- Design and execute routine studies to investigate the PK/PD and efficacy of drug candidates.
- Perform routine to intermediate handling procedures and injections, monitor animal health, and collect tissues in mice.
- Perform moderately complex behavioral experiments in animal models.
- Support the implementation of new animal models.
- Demonstrate technical proficiency to investigate, identify, develop, optimize, and troubleshoot new methods/ techniques/ instrumentation to address critical project needs.
- Read and understand scientific literature.
- Analyze data, author technical reports, and document experiments in an electronic notebook.
- Participate and present at project team and departmental meetings.
- Maintain laboratory organization including equipment upkeep and ensure compliance with safety protocols.
- Collaborate across functional areas.
Required Skills & Experience:
- S with 7+ years post-graduate experience or M.S. with 4+ years of experience working in a biotechnology or pharmaceutical company or contract research organization.
- Experience working with animal disease models.
- Experience with animal behavioral assays.
- Experience with subcutaneous and intravenous injections in rodents; intracerebroventricular injection experience a plus.
- Experience with molecular biology assays such as PCR, ELISA, MSD, BCA, Western Blot (or JESS).
- Strong organizational skills and attention to detail.
- Strong verbal and written communication skills.
- Creative thinking and working well in a team environment.
- Experience in neuroscience a plus.
- Experience with ISH/IHC a plus.
Location(s):
Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in our Bedford, MA location.
Travel:
This position will require approximately 0% travel.
Culture & Values:
At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.
Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do.
Benefits & Compensation:
At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.
Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center.
For more information, visit stoketherapeutics.com or follow the company on X at @StokeTx.
All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.
Stoke participates in E-Verify.
