Principal Scientist, ASO Biologist bei GondolaBio LLC

Description

About GondolaBio  

GondolaBio is a clinical-stage biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Originally launched as BridgeBioX, a subsidiary of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. The company aims to leverage cutting-edge biological research to create breakthrough medicines addressing high unmet needs across multiple therapeutic areas, including neurology, pulmonology, cardiology, nephrology, and endocrinology. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation. 

Who you are 

We're seeking an entrepreneurial scientific leader who combines intellectual rigor with practical execution skills to advance our antisense oligonucleotide (ASO) pipeline at GondolaBio. You will serve as a scientific lead for multiple preclinical ASO programs which will involve collaboration with the n-Lorem foundation. You will play a pivotal role in designing, executing, and interpreting experiments. This position offers the opportunity to shape research strategy while mentoring junior scientists and contributing to a growing, interdisciplinary team. 

Requirements 

Key Responsibilities 

• Serve as a subject matter expert for ASO discovery, design, and preclinical evaluation across multiple programs 
• Lead the design and execution of in vitro studies across multiple preclinical programs using the ASO modality 
• Develop and optimize functional assays and disease models (e.g., iPSC-derived and patient primary cell-derived) to support target engagement and efficacy assessments 
• Perform and interpret molecular, protein, and functional analyses (e.g., qPCR, Western blot), integrating findings with in vivo and translational data 
• Design and interpret in vivo efficacy, safety, and target engagement experiments for ASOs in multiple indications 
• Supervise and mentor junior scientists, fostering a high-performing and collaborative research environment 
• Oversee external research activities, including CRO and academic collaborations, ensuring high-quality and timely data delivery 
• Stay abreast of emerging science, engage with external experts, and represent the company at scientific meetings 
• Communicate results and strategic insights to senior leadership; contribute to publications and IP 
• Partner with leadership to shape and execute a cohesive research strategy that advances program objectives across discovery and translational stages 

Education, Experience, & Skills Requirements 

• PhD in chemistry, biology, or a related field with 4+ years of industry experience; strong publication record is a plus 
• Modality expertise in ASOs and experience with preclinical discovery, design, and testing of ASO efficacy and safety 
• Experience with in vitro and in vivo disease models across multiple therapeutic areas (neuroscience and renal experience is a plus) 
• Proficiency in preclinical ASO experiments, including qPCR, Western blot, iPSC and patient primary cell culture 
• Sound knowledge of disciplines involved in drug discovery (cell-based disease models, target engagement and target modulation assays, cell viability assays, biomarker discovery, PD/PK, and efficacy studies) and experience with plate-based cellular and biochemical assays 
• Demonstrated ability to manage projects and lead junior team members 
• Strong problem-solving, communication, and cross-functional collaboration skills 
• Experience in biotech or pharmaceutical R&D preferred 

No matter your role at GondolaBio, successful team members are: 

• Patient Champions, who put patients first and uphold strict ethical standards 
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset 
• Truth Seekers, who are detailed, rational, and humble problem solvers 
• Individuals Who Inspire Excellence in themselves and those around them 
• High-quality executors, who execute against goals and milestones with quality, precision, and speed 

What We Offer  

• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts  
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak  
• An unyielding commitment to always putting patients first.  
• A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science  
• A place where you own the vision – both for your program and your own career path  
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game  
• Access to learning and development resources to help you get in the best professional shape of your life  
• Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)  
• Flexible PTO  
• Rapid career advancement for strong performers  
• Potential ability to work on multiple GondolaBio Pharma programs across multiple therapeutic areas over time  
• Partnerships with leading institutions  
• Commitment to Diversity, Equity & Inclusion  

The base pay range for this position is $190,000 to $205,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location.  A bonus plan and equity will also be offered.