Hybrid PTI - Neurodegenerative Disease Senior Scientist bei Convergentresearch
Convergentresearch · Watertown, MA, Vereinigte Staaten Von Amerika · Hybrid
- Optionales Büro in Watertown, MA
Parallel Squared Technology Institute (PTI) is a non-profit research institute developing technologies, reagents, and computational tools to increase the sensitivity and throughput of protein analysis, with a specific focus on single-cell proteomics. We are applying these innovations to societally-relevant areas of biomedical research. As part of these efforts, we are developing new approaches to study protein dysfunctions in Alzheimer’s and related neurodegenerative diseases.
Why? Protein dysfunctions directly cause many diseases, such as Alzheimer’s disease. Yet, proteins remain understudied because of technological hurdles.
How? To resolve these limitations, PTI will develop mass tags enabling a new framework for multiplexed protein analysis by mass spectrometry towards achieving 100-fold increase in throughput. Scientists at and collaborating with the institute will use these gains to directly investigate disease mechanisms and resolve problems that have proven intractable for decades. Our proof of principle technology and strategies are outlined at: parallelsq.org.
New career opportunities
Members of PTI will be supported with industry-level resources to lead research projects and disseminate their discoveries and innovations to the broader biomedical community through frequent publications, presentations, and submissions to public data portals.
Summary of Position
We are seeking scientist and senior scientist candidates to help drive our efforts to use single-cell proteomics to understand the causes of Alzheimer’s and related neurodegenerative diseases. Ideal candidates will have expertise in the molecular mechanisms of neurodegeneration and direct, hand-on experience in single-cell analysis, computational biology, and brain tissue handling.
Candidates will have the opportunity to work as part of an interdisciplinary team in multiple areas, including on NIH-funded projects, using proteomic technologies developed at PTI to discover new molecular mechanisms of neurodegeneration in Alzheimer’s and related disorders. Day-to-day responsibilities include designing and carrying out experiments to isolate and profile single cells from brain tissue, computationally analyzing large-scale single-cell proteomics datasets, preparing manuscripts and presentations, mentoring junior scientists, and regular meetings with collaborators in and outside of PTI. Candidates will initially work on ongoing projects but will have the opportunity to design and lead their own projects as well.
Candidates with less than 1 year of postdoctoral experience will be considered for the scientist position and those with more than 1 year of experience will be considered for the senior scientist position.
