Senior Project Toxicologist (Basel, BS, CH) chez Idorsia

About Idorsia Pharmaceuticals Ltd
Headquartered near Basel, Switzerland – a European biotech hub – Idorsia has a highly experienced team of dedicated professionals, covering all disciplines from bench to bedside; QUVIVIQ™ (daridorexant), a different kind of insomnia treatment with the potential to revolutionize this mounting public health concern; strong partners to maximize the value of our portfolio; a promising in-house development pipeline; and a specialized drug discovery engine focused on small-molecule drugs that can change the treatment paradigm for many patients.

We are seeking an experienced and visionary  Senior Project Toxicologist to join our Nonclinical Safety team.

This strategic role will be responsible for leading the nonclinical safety assessment of drug candidates across multiple therapeutic areas, from early discovery through to registration and beyond. 

You will serve as the key toxicology representative on cross-functional project teams, providing expert guidance on safety strategy, regulatory interactions, and risk assessment. This is a high-impact role with visibility across the organization and the opportunity to shape the future of our pipeline. 

Job Responsibilities

• Lead nonclinical safety strategy for assigned drug development programs, ensuring alignment with regulatory expectations and internal standards. 
• Design, oversee, interpret and report toxicology and safety pharmacology studies (GLP and non-GLP) to support candidate selection, and clinical development at all stages IND/CTA submissions, and global regulatory filings. 
• Represent Toxicology on cross-functional project teams and governance bodies, providing expert input on safety risks and mitigation strategies. 
• Prepare and review regulatory documents including IBs, INDs, CTAs, NDAs, and responses to health authority queries. 
• Engage with global health authorities to support regulatory submissions and defend safety packages. 
• Collaborate closely with colleagues in Pharmacology, DMPK, Clinical, Regulatory Affairs, CMC and other functions. 
• Preparation of toxicological expert statements for impurities and excipients, cleaning validation, worker's safety  
• Liaising with key consultants and scientists in the field 
• Mentor junior toxicologists and contribute to the strategic development of the Nonclinical Safety department. 

Candidate Requirements

• PhD, DVM, or equivalent in Toxicology, Pharmacology, Veterinary Medicine or related life sciences field. 
• Minimum of 10 years of industry experience in nonclinical safety assessment, with a strong track record of supporting drug development programs. 
• Proven experience in regulatory submissions and interactions with global health authorities. 
• Deep understanding of toxicology study design, interpretation, and regulatory requirements. 
• Excellent communication, leadership, and influencing skills. 
• Ability to manage multiple projects and priorities in a fast-paced environment. 
• Board certification (e.g., ERT, DABT) is highly desirable. 
• Experience in multiple therapeutic areas with small molecules 
• Knowledge about SEND compliant documentation is desirable  
• Excellent command of English, both oral and written  

Work  Location: Allschwil

Country: Switzerland

Business Area: Research - Pharmacological Sciences

Schedule: Fulltime

Job Type: Permanent

Job Level : Director or Senior Director depending on experience

Job ID: 4650

At Idorsia, we harness the power of difference, authenticity, and inclusion to achieve business success.
We encourage all potential candidates with diverse backgrounds of race, color, religion, sexual orientation, gender identity, age, national origin, and disability to submit their job applications. All applicants will receive consideration.
We are committed to fostering respect, fairness, and equal opportunities for all job applicants and our employees.

Please be informed that if you are selected for this position, your employment will be subject to a pre-employment background screening process, of which you would be informed in greater detail in due course.

Idorsia Pharmaceuticals Ltd ("Idorsia") is committed to a fair and transparent application process. In order to avoid any conflict of interest in line with Idorsia Code of Business Conduct, which would undermine such a commitment, the applicants  must disclose any personal, financial, or other outside interests interfering with the interests of Idorsia. Further, the applicant is obliged to disclose any and all relationships with close or affiliated persons, who are employees of Idorsia or are collaborating with Idorsia in any other contractual relationship. 

Please note Idorsia operates a strictly controlled list of preferred recruitment partners. For those partners who have no valid, signed Master Service Agreement in place with Idorsia, all unsolicited resumes, CVs, anonymous profiles, or any other candidate details submitted through our website or to personal e-mail accounts of employees of Idorsia Pharmaceuticals (including any of its subsidiaries, affiliates, or related companies) are considered the property of Idorsia Pharmaceuticals and are not subject to payment of any form of introduction, placement or referral fees.