Principal Scientist, Medicinal Chemistry - Discovery Chemistry chez Janssen Research & Development, LLC (6084)

Janssen Research and Development, LLC, amember of Johnson and Johnson's Family of Companies, is recruiting for a Principal Scientist, Medicinal Chemistry - DiscoveryChemistry, located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson &Johnson, we are working to create a world without disease. Transforming livesby finding new and better ways to prevent, intercept, treat and cure diseaseinspires us. We bring together the best minds and pursue the most promisingscience.

We are Janssen. We collaborate with the world for the healthof everyone in it. Learn more at www.janssen.com and follow us@JanssenGlobal. Janssen Research & Development, LLC is part of theJanssen Pharmaceutical Companies.

Discovery Chemistry is an integral andgrowing part of the Janssen Discovery, Product Development & Supply (DPDS)group, which is committed to the delivery of high-quality drug candidates inpartnership with all six Therapeutic Area (TA) discovery organizations. TheDPDS mission requires deep scientific expertise in multiple disciplinesincluding chemistry, cellular and molecular pharmacology, enzymology, andscreening technologies coupled with an ability to work collaboratively withinternal and external organizations. 

Building on a strong legacy of success, weare currently recruiting an outstanding individual to join our Spring House,Pennsylvania, based team as Principal Scientist, Medicinal Chemistry, DiscoveryChemistry – a role that offers tremendous growth opportunity within a dynamicand science-driven organization.  Located in suburban Philadelphia, theJanssen Spring House campus sits at the heart of the thriving mid-Atlanticbiopharmaceutical belt, offering easy access to some of nation’s premiereeducational, research, and medical centers of excellence. 

We are seeking an experienced, highly skilled, andmotivated chemist with excellent organicsynthesis and medicinal chemistry expertise to lead small molecule drugdiscovery programs and advance them toward the clinic.  Thisposition will require the candidate to possess and leverage deep knowledge andcapabilities to deliver differentiated clinical candidates to the Janssenproduct development pipeline within our Disease and Pathway Area Stronghold(DAS and PAS) strategy.  Using a mix of internal and external resources,the Principal Scientist will partner with key stakeholders in the TAs and otherinternal groups, represent medicinal chemistry, lead cross-functional projectteams, and be co-responsible for building, managing, and delivering highquality clinical molecules. 

• As a dynamic project leader,drive and direct medicinal chemistry functions for one or more drug discoveryprojects, working in concert with partners in molecular and cellular biology,pharmacology, computational chemistry, ADME, structural biology, chemicaldevelopment, and other key functions
• Work collaboratively with otherJanssen drug discovery sites, including Boston, MA, La Jolla, CA, South SanFrancisco, CA, and Beerse, Belgium, and with Johnson & Johnson InnovationCenters worldwide
• Analyze screening data, performliterature reviews, design, propose, and execute medicinal chemistry plans,coordinate chemistry and biology data to support compound progression andpatent strategies
• Provide scientific direction andleadership for synthetic and medicinal chemistry activities of internal FTEs
• Supervise and direct syntheticchemistry activities at contract research organizations (CROs)
• Participate in portfolio andstage-gate reviews, lead the preparation and presentation of dossiers forclinical candidate nomination and compound advancement
• Participate in shaping andimplementing strategies that support medicinal chemistry growth objectives atJanssen
• Serve as a scientific expert inmedicinal chemistry with both internal and external partners and providerecommendations regarding new targets and emerging external opportunities
• Ensure optimalinteraction/communication and provide updates on project status to drugdiscovery leadership
• Maintain a significant level of productivity in thelaboratory setting

%3Cul%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EPhD in synthetic organic or medicinal%0Achemistry is required%3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EPostdoctoral%0Aexperience is preferred %26nbsp;%3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EA%0Aminimum of 7 or more years’ experience in the biopharmaceutical industry with a%0Aproven track record of innovative projects and key contributions to clinical%0Acandidate selection, is required %3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EExperience%0Aas a project leader in the biopharmaceutical industry is preferred%3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EBroad%0Aexperience and proven accomplishments in medicinal chemistry is required%3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EExperience%0Ain one or more therapeutic areas is preferred%3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EDemonstrated%0Aoperational skills for managing discovery programs at the level of a senior%0Achemist/team leader are required %3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EA proven%0Atrack record of delivering clinical candidates is strongly preferred%3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EExpert%0Aknowledge of modern methods of synthetic and medicinal chemistry with ability%0Ato successfully and simultaneously conduct medicinal chemistry on multiple%0Aprojects is required %3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3ESolid%0Aunderstanding of cellular/molecular biology, biochemistry, disease%0Apharmacology, mechanisms of drug metabolism and molecular toxicology,%0Apharmaco-kinetic and pharmaco-dynamic sciences, and formulations for the %3Ci%3Ein vivo%3C/i%3E evaluation of drug candidates is%0Arequired %3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EThorough%0Aunderstanding of DNA-encoded library technologies and protein target%0Adegradation strategies is preferred %3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EKnowledge%0Aof and/or experience with computational chemistry methods and biophysical%0Atechniques such as X-ray crystallography and macromolecular NMR is required %3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EAbility%0Ato integrate multiple R%26amp;D disciplines into a successful strategic project%0Aplan is required %3C/font%3E%3C/li%3E%3Cli%3E%3Ca name=%22_Hlk510008269%22%3E%3Cfont face=%22Arial%22 size=%223%22%3EStrong%0Aproblem-solving skills for developing creative, innovative solutions, and%0Ameeting project objectives are required %3C/font%3E%3C/a%3E%3C/li%3E%3Cli%3E%3Ca name=%22_Hlk510006067%22%3E%3Cfont face=%22Arial%22 size=%223%22%3EDemonstrated influence, negotiation, and conflict resolution%0Askills, including the ability to succeed within a matrix environment, are%0Arequired %3C/font%3E%3C/a%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EExperience%0Ain managing project budgets, aligning actions with overall strategy, and%0Asupporting business cases for decision-making is preferred %3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EStrong%0Atrack record of scientific contributions including peer reviewed first-author%0Apublications, patent applications, and presentations at major national meetings%0Ais required %3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3ERecord%0Aof maintaining a strong lab presence and commitment to invest up to 30% of time%0Ain the lab is required%3C/font%3E%3C/li%3E%3Cli%3E%3Cfont face=%22Arial%22 size=%223%22%3EUp to%0A10% travel is required%3C/font%3E%3C/li%3E%3C/ul%3E%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%0A%3Cdiv%3E%3Cfont face=%22Arial%22 size=%223%22%3E%26nbsp;%3C/font%3E%3C/div%3E%0A%0A%3Cp style=%22margin-top:0px;margin-bottom:0px%22%3E%3Cfont face=%22Arial%22 size=%223%22%3EJohnson %26amp; Johnson is an Affirmative Action and Equal Opportunity%0AEmployer. All qualified applicants will receive consideration for employment%0Awithout regard to race, color, religion, sex, sexual orientation, gender%0Aidentity, age, national origin, or protected veteran status and will not be%0Adiscriminated against on the basis of disability.%26nbsp;%3C/font%3E%3C/p%3E%0A%3Cbr _moz_editor_bogus_node=%22TRUE%22%3E Postuler maintenant