Senior Clinical Program Manager chez Revolution Medicines

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

This is a unique opportunity for a Sr. Clinical Program Manager (Sr. CPM). You will be responsible for providing strategic clinical operations leadership across a portfolio of trials, ensuring operational excellence and full accountability for trial execution.  This position will report into the Associate Director, Clinical Operations.

Responsibilities:

• Apply extensive industry experience and exercise wide latitude in determining objective and approve significantly complex, multi-discipline or function-wide assignments.

• Oversee the execution of the Clinical Study Execution Team (CSET) meetings and provide strategic context and clarity where needed.

• Oversee operational delivery across multiple study(ies).

• Lead multiple departmental or interdepartmental strategic initiatives as it relates to broader organizational topics. Known as the subject matter expert and point of contact for specific study trial(s).

• Ensure inspection readiness and quality compliance.

• Provide operational input into protocol design, study documents, and regulatory submissions.

• Ensure alignment and consistency across trial teams, vendors, and systems.

• Oversee the development of RFPs and selection of CROs/vendors.

• Trian CROs, vendors, investigators, and study coordinators, as well as cross-functional partners on study requirements.

• Oversee vendor management develop strong collaborative relationship with internal and external stakeholders.

• Review, approve, and manage study-level budget and drive cost control.

• Identify resourcing needs and lead the recruiting and hiring process, as well as make the decision for hiring.

• Mentor and train Clinical Program Managers (CPMs), Clinical Trial Managers (CTMs), Clinical Trial Management Associates (CTMAs), and Clinical Trial Assistants (CTAs).

• Manage individual contributors including performance management.

• Conduct risk management, contingency, and scenario planning.

• Participate in other Clinical Operations activities as appropriate.

Required Skills, Experience and Education:

• BS, BA, or RN in a relevant scientific discipline.

• 10+ years of relevant experience in the pharmaceutical or biotech industry, preferably in Clinical Operations or Clinical Research related experience.

• Expert knowledge of FDA and EMA Regulations, ICH Guidelines, GCP, and familiarity with standard clinical operating procedures.

• Effective cross-functional team management.

• Strong project leadership and decision-making with advanced problem-solving and communication skills.

• Manage studies or programs of higher complexity from both a process and strategic perspective.

• High sense of priority and commitment to excellence in the successful execution of deliverables.

• Successful experience with teams analyzing operational data, emphasis on quality, timeliness and fiscal responsibility, lead decision making, anticipate challenges, and execute on goals as the leader of an interdisciplinary team.

• Travel may be required (~25%).

Preferred Skills:

• Decision-making skills.

• Has familiarity working with vendor systems/portals (e.g., eTMF, EDC, IRT, CTMS).

• Oncology experience, early and/or late stage, strongly preferred. #LI-Hybrid #LI-JC1