Senior Director, IT Operations presso Madrigalpharma

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Job Summary:

The Sr. Director, IT Operations reports to the CIO operating as their strategic extension, provide enterprise leadership for end-to-end IT Operations, spanning applications, cloud/infrastructure, data & analytics, AI/ML enablement, and end-user experience, while orchestrating IT governance, portfolio and financial management, vendor performance, ITIL-based service management, and executive communications; integrate domain roadmaps and service delivery to ensure secure, compliant (SOX/GxP), and scalable services for R&D, Quality, Supply Chain, Finance, and Legal; establish the rhythm of business and transparent metrics to drive clear decisions, brief the ELT/Board on performance, risk, and investment trade-offs, and build strong cross-functional partnerships that deliver measurable outcomes.

Position Specific Responsibilities:

• Own and run the IT operating cadence (LT meetings, quarterly business reviews, portfolio reviews, decision and action logs), ensuring crisp follow-through and accountability.
• Lead IT service management (incident, problem, change, request, knowledge) and continuous improvement, serving as process owner and champion for ITIL practices.
• Oversee the IT project/portfolio pipeline in partnership with PMs and functional leads; ensure intake, prioritization, resource/capacity planning, and benefits realization are transparent and data-driven.
• Drive IT financial management in partnership with Finance: annual planning, forecast accuracy, OpEx/CapEx tracking, vendor/SOW oversight, and TCO optimization.
• Coordinate enterprise compliance activities impacting IT (e.g., SOX ITGCs, GxP/CSV controls, data integrity, privacy), partnering with Quality, Internal Audit, and Security.
• Monitor service reliability and risk (SLAs/OLAs, availability, DR/BCP readiness); lead post-incident reviews and drive corrective/preventive actions.
• Establish and publish IT KPIs/OKRs and executive dashboards; translate technical performance into business outcomes for the ELT and key stakeholders.
• Lead cross-functional initiatives; prepare briefs, board/ELT materials, and communications that enable timely decisions.
• Manage vendor ecosystem (MSPs, SaaS/IaaS providers, professional services): performance reviews, renewals, RFPs, and commercial negotiations in partnership with Procurement/Legal.
• Lead or supervise a small team (e.g., IT operations managers/analysts and/or PMs) and provide dotted-line leadership to managed service partners.
• Champion change management and adoption for new services and standards; ensure clear stakeholder engagement across R&D, Quality, Supply Chain, Finance, and Legal.
• Identify and standardize critical IT processes; simplify and document procedures to support scalability and audit readiness.
• Advance a culture of safety, security, compliance, and customer service within IT; model inclusive leadership and coach team members.

Specialized Knowledge & Skills:

• Deep knowledge of IT operations and service management frameworks (ITIL v4); experience with ITSM platforms (e.g., ServiceNow) and automation.
• Strong portfolio/PMO, governance, and financial acumen (budgeting, forecasting, TCO, business cases).
• Familiarity with life-sciences regulatory context: GxP/CSV (e.g., 21 CFR Part 11, Annex 11, GAMP 5), SOX ITGCs, data integrity, and audit readiness.
• Excellent executive communication, storytelling, and slide writing; able to distill complexity into clear options and recommendations.
• Influences without authority; drives alignment among executives and cross-functional stakeholders.
• Analytical problem-solver with command of metrics, dashboards, and root-cause analysis; comfortable with ambiguity and rapid context-switching.
• Vendor and contract management, SOW development, and performance governance.
• Change leadership and organizational effectiveness skills; builds team capability and fosters continuous improvement.

Educational Requirements:

Identify the educational qualifications that an employee must possess to perform the job duties and responsibilities satisfactorily.

• Bachelor’s degree in Information Systems, Computer Science, Engineering, Business, or related field.
• Advanced degree (MBA or related) preferred.
• Relevant certifications preferred: ITIL v4, PMP/PRINCE2; COBIT and/or SAFe a plus.

Experience:

• 15+ years of progressive IT experience with significant time in IT operations/service management and/or IT PMO; 4+ years in a leadership role.
• Demonstrated success operating as a chief-of-staff or equivalent strategic operator for a technology executive.
• Experience in biotech/pharma or other regulated industries strongly preferred.
• Track record leading cross-functional portfolios, improving SLAs/OLAs, and maturing ITIL processes.
• Hands-on experience with IT financial management, vendor/SOW oversight, and contract negotiations.
• Proven ability to prepare executive materials and drive decisions with data and clear tradeoffs.

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $254,700 to $311,300 per year.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].