Scientist/Senior Scientist – Discovery RLT presso Lilly

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

The Discovery Scientist will support the advancement of new ligands being developed for Eli Lilly’s oncology pipeline. The role’s primary duties are to provide technical scientific support for Lilly’s early discovery programs, including but not limited to: Characterization of new ligands in biochemical/biophysical assays, maintenance and expansion of mammalian cell culture banks, and protein conjugation and purification methods.  This position will require accurate and detail-oriented execution of experimental work in close collaboration with on-site scientists and team members at other Lilly sites.

Roles and responsibilities

• Independently perform routine biochemical and/or cell-based assays to characterize the activity of early-stage ligands, including enzymatic activity assays, cytotoxicity assays, ELISAs, and functional reporter assays
• Passage and prepare mammalian cells to be used in assays and in vivo studies
• Determine binding affinity and kinetic parameters of protein-ligand interactions through biophysical techniques (SPR, BLI, DSF).
• Perform conjugation and purification of protein-based ligands by FPLC.
• Assist with sample processing (serum, tissue samples, etc) to support biodistribution and metabolite profiling
• Interface with external vendors to support early discovery activities.
• Critically assess data and methods, adapting and adjusting procedures as necessary.
• Fully adhere to Lilly Discovery Quality standards
• In conjunction with managers, establish priorities and meet timelines for key experiments.
• Provide clear communication of scientific data to co-workers through internal presentations and written methods.

Required Qualifications
 

• B.Sc. or M.Sc. in biochemistry, biology, chemistry, pharmacy, or related discipline
• 3+ years relevant postgraduate experience (industry preferred)  
• Demonstrated success independently designing experiments and analyzing scientific data
• Experience performing in vitro biochemical/biophysical assays.
• Experience with mammalian cell culture and aseptic techniques.
• Strong background in performance of cell-based reporter assays and cytotoxicity assays.
• Familiarity with protein analysis and purification methods
• Ability to communicate scientific data effectively to an interdisciplinary team.
• Excellent problem-solving and decision-making skills. 
• Working knowledge of MS Office, Graphpad Prism, and ChemDraw. 

Additional preferences

• Experience with radiobinding assays or handling of radioactive materials is an asset.
• Experience with confocal microscopy, immunofluorescence and imaging of live/fixed cells is an asset.

Additional Information:

Physical Demands/Travel:

The physical demands of this job are consistent with a lab environment.   

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a Laboratory environment.  

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Location of work 
The position will be working onsite at a lab in Toronto, ON, with the anticipation of travel for team and client meetings (up to 2 instances per calendar year).

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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