Research Scientist, Discovery Toxicology - Princeton, NJ presso Bristol Myers Squibb (BMS)

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Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 

Overview: We are seeking an experienced Research Scientist who will work in a dynamic, multidisciplinary matrixed team within our Lawrenceville, N.J. Discovery Toxicology organization to generate and interpret data from in vitro and in vivo studies supporting nonclinical safety assessment.  The successful candidate will engage in investigative studies that support early toxicity and teratogenicity assessment using in vitro models and New Approach Methodologies (NAMs) - e.g. Zebrafish model, microphysiological systems (MPS) and organoids - and will also support in vivo studies with mechanistic investigations and pharmacodynamic assessments for programs in a wide variety of therapeutic areas.  This individual will conduct experimental work, analyze data and report results of compounds in the Discovery pipeline to provide early assessment of toxicity or teratogenic liabilities, identification of pharmacodynamic or toxicity biomarkers, as well as inform on potential mechanisms of toxicity/teratogenicity. State-of-the-art cell culture and molecular biology is required, and flow cytometry, experience working with developmental model systems, and gain-/loss-of-function approaches are highly desirable.  Educational and research background in toxicology, cell biology, developmental biology, or a related field is required.

Key Responsibilities

Evaluate toxicity and teratogenic liability assessments for early Discovery candidates including literature-based assessments, design and execution of investigative studies and reporting of these assessments.
Apply molecular biology and flow cytometry expertise to develop and optimize assays for evaluating toxicity endpoints and Bio- / pharmacodynamic (PD) markers associated with investigative safety assessments and issue resolution.
Apply approaches for functional assessment of drug targets or suspect off-targets such as siRNA, antisense oligonucleotides, and/or CRISPR.
Apply expertise above with expertise in in vitro cellular and developmental model systems to conduct investigative mechanistic studies to characterize on- or off- target liabilities to support discovery programs.
Apply multifaceted data analysis including use of specialized data analysis software for flow cytometry and gene or protein expression data. 
Study direct, execute, and report in vitro or in vivo studies evaluating toxicity or teratogenicity.
Author internal reports and manuscripts associated with exploratory/investigative activities in scientific journals, present research work internally and at external conferences.
Responsible for maintaining excellent documentation of laboratory procedures and recording of data in compliance with standards defined by BMS corporate notebook policies and procedures. 
Create an atmosphere of scientific excellence, collaboration, open communication, and creativity in order to maximize productivity.