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Senior Scientist – Oligonucleotide Synthesis Chemist  

Working at Abbott

At Abbott, you can do work that matters, grow, and learn, care for yourself and your family, be your true self, and live a full life. You’ll also have access to:

• Career development with an international company where you can grow the career you dream of.

• Employees can qualify for free medical coverage in our Health Investment Plan (HIP) PPO medical plan in the next calendar year.

• An excellent retirement savings plan with a high employer contribution

• Tuition reimbursement, the Freedom 2 Save student debt program, and FreeU education benefit - an affordable and convenient path to getting a bachelor’s degree.

• A company recognized as a great place to work in dozens of countries worldwide and named one of the most admired companies in the world by Fortune.

• A company that is recognized as one of the best big companies to work for as well as the best place to work for diversity, working mothers, female executives, and scientists.

The Opportunity

The Oligonucleotide Synthesis Chemist will work on site out of our San Diego, California office Infectious Disease division. The person hired will help lead a team of scientists responsible for oligonucleotide synthesis to help drive product development efforts, ultimately enabling commercialization of diagnostic tests as well as driving future improvements and applications. 

What You’ll Work On

• Support R&D and product development efforts by providing expertise in nucleic acid chemistry and oligonucleotide synthesis, analysis and purification 

• Identify, implement and optimize novel/new synthesis processes 

• Develop and implement analytical and biophysical methodologies to help analyze, characterize and evaluate raw materials and finished products 

• Operate and maintain DNA synthesis and purification equipment 

• Synthesize small molecules using a variety of organic chemistry techniques 

• Investigate problem areas and areas of desirable product improvement 

• Manage projects by coordinating and prioritizing work streams, timelines and deliverables while driving project execution to meet corporate expectations 

• Resolve technical issues with analytical methods and instrumentation 

• Work both independently and as part of a cross-functional team to analyze, interpret, report, provide conclusions and present experimental data internally 

• Provide high level analysis of experimental results 

• Work as part of a multi-disciplinary team with other scientists, chemists, engineers and manufacturing personnel 

• Bachelor's Degree in biological or physical sciences, or mathematics; with 6 + years of progressively responsible positions in a research development environment. Or M.S. with minimum of 4 years' experience or Ph.D. in chemistry, analytical chemistry, or a closely related field.

• Minimum six years of experience working in the IVD field in an industrial setting, or in a clinical, central or core laboratory performing oligonucleotide synthesis and post-synthesis modifications as well as analytical characterization of oligos.   

• Proven track record of strong technical skills and hands-on experience with a diverse array of molecular and analytical testing methods  

• Demonstrated expertise in nucleic acid manipulation, enzymology, and biochemistry as it relates to nucleic acid synthesis and measurement 

• Demonstrated ability to work independently or as part of a team to achieve desired results from general objectives 

• Demonstrated ability to communicate effectively 

Preferred Qualifications  

• Experience and expertise in performing oligonucleotide synthesis and post-synthesis modifications as well as analytical characterization of oligonucleotides Hands-on experience building oligonucleotides with modifications, including various attachment chemistries, linkers, fluorophores, quenchers, modified bases, etc… 

• Demonstrated expertise in small molecule synthesis using a variety of organic chemistry techniques.  

• Ability to independently develop, optimize and validate analytical methods  

• Experience developing analytical methods for the characterization of clinical samples 

• Demonstrated ability to lead complex projects with minimal supervision 

• Inventive, with ability to implement ideas in the laboratory 

• Demonstrated ability to analyze, interpret, and present data are essential 

• Hands-on experience with multiple analytical instruments and methodologies, including mass spectrometry, HPLC, spectroscopy (UV-Vis), capillary electrophoresis, SDS-PAGE, OES-ICP, DSC, TGA as well as with a variety of wet chemistry methodologies is a plus