Deep Genomics is at the forefront of integrating artificial intelligence and complex biology to transform drug discovery. Our proprietary machine learning platform decodes the complexity of RNA biology to identify novel drug targets, mechanisms and therapeutics inaccessible through traditional methods. With expertise spanning machine learning, drug development, bioinformatics, data science, genetics and chemistry, our multidisciplinary team in Toronto and Cambridge, MA is revolutionizing how medicines are created.
About the role
The Principal Research Associate will join our Platform Biology team and will be a key player in driving our cutting-edge AI RNA therapeutics discovery platform. In this role, you will be responsible for helping characterize our novel compounds, including performing automated high-throughput arrayed screening, as well as downstream characterization of these molecules. Further, you will be instrumental in helping develop, optimise and implement novel cellular and protein assays to advance our internal therapeutics portfolio. The ideal candidate will have strong cell biology expertise, and hands-on experience using primary hepatocyte cells. Relevant knowledge of RNA modalities such as ADAR, ASO, mRNA and/or siRNAs is also highly beneficial. The successful candidate should demonstrate initiative, technical ownership and be able to thrive in a dynamic work environment with cross-functional teams working together to achieve company goals.
This position is onsite at our Cambridge, MA site.
Key Responsibilities
Design, optimise and execute robust cell-based assays, to support compound screens and lead optimisation.
Culture, maintain and transfect a variety of mammalian cell lines, such as immortalized cell lines, primary cells and co-culture systems, and onboard new cell types and systems to enable drug discovery.
Examine important molecular and functional endpoints in vitro, including RNA and protein readouts, to better understand our molecules in our internal therapeutic pipeline.
Perform standard molecular biology techniques (e.g. PCR, qPCR, Jess/Leo Automated Westerns, ELISA, Western blot, etc.).
Collaborate with a cross-functional team in a dynamic, matrixed environment to achieve shared company deadlines, and communicate experimental design and findings with colleagues and project teams.
Clearly document experiments, standard operating procedures (SOPs) and data in an electronic lab notebook (ELN).
Basic Qualifications
BS or MS in Biology, Molecular Biology, Genomics, Biochemistry or a related field with 4+ years of relevant pharmaceutical or biotechnology experience.
Strong hands-on experience growing, maintaining and transfecting mammalian cell lines.
Good understanding of molecular and cell biology.
Experienced in design and execution of molecular and cellular assays, including documentation in an electronic lab notebook (ELN).
Excellent communication, organizational skills and a willingness to learn.
Ability to prioritise and drive work independently in a fast-paced, technical and data-rich environment.
Preferred Qualifications
Hands-on experience using primary hepatocytes is strongly preferred.
Proficiency in automated Western blotting methods, such as the Jess/Leo platforms.
Flow cytometric experience is a plus.
Experience with high-throughput liquid handlers (e.g. Beckman Echo, Agilent Bravo and/or Hamilton STAR/STAR V).
Next-generation sequencing library preparation, e.g. amplicon sequencing.
Past experience with RNA editing and/or RNA oligonucleotides.
Demonstrated experience working in cross-functional teams.
What We Offer
A collaborative and innovative environment at the frontier of computational biology, machine learning, and drug discovery.
Highly competitive compensation, including meaningful stock ownership.
Comprehensive benefits - including health, vision, and dental coverage for employees and families, employee and family assistance program.
Flexible work environment - including flexible hours, extended long weekends, holiday shutdown, unlimited personal days.
Maternity and parental leave top-up coverage, as well as new parent paid time off.
Focus on learning and growth for all employees - learning and development budget & lunch and learns.
Facilities located in the heart of Toronto - the epicenter of machine learning and AI research and development, and in Kendall Square, Cambridge, Mass. - a global center of biotechnology and life sciences.
Additional Information
Deep Genomics encourages applications from all backgrounds who seek the opportunity to build the world's leading AI-driven genetic medicine company.
If you have a disability or special need, accommodation is available on request for candidates taking part in all aspects of the selection process.
*This posting reflects a current vacancy.
We offer competitive compensation aligned with local market benchmarks. The salary range for this role is $115,000 - 135,000, and reflects Cambridge, USA-based roles.
Estas cookies son necesarias para que el sitio web funcione y no se pueden desactivar en nuestros sistemas. Puede configurar su navegador para bloquear estas cookies, pero entonces algunas partes del sitio web podrían no funcionar.
Seguridad
Experiencia de usuario
Cookies orientadas al público objetivo
Estas cookies son instaladas a través de nuestro sitio web por nuestros socios publicitarios. Estas empresas pueden utilizarlas para elaborar un perfil de sus intereses y mostrarle publicidad relevante en otros lugares.
Google Analytics
Anuncios Google
Utilizamos cookies
🍪
Nuestro sitio web utiliza cookies y tecnologías similares para personalizar el contenido, optimizar la experiencia del usuario e indvidualizar y evaluar la publicidad. Al hacer clic en Aceptar o activar una opción en la configuración de cookies, usted acepta esto.
Los mejores empleos remotos por correo electrónico
¡Únete a más de 5.000 personas que reciben alertas semanales con empleos remotos!