Instructor en Case Western Reserve University

The Instructor will be exploring mRNAs subject to translational control by Bmal1 during ER stress and determining their contribution to cell fate.  This faculty member will make observations that Bmal1-dependent regulation of mRNA translation influences not only cell fate, but also tumor cell response to targeted therapies.  Two specific areas of focus will be regulation of mRNAs that regulate pro-apoptotic function and their role in cell stress and also negative regulation of pro-survival mRNAs during cell stress and tumorigenesis.  These experimental approaches will entail use of cell and animal models and will form the basis of her research focus.