Process Development Associate I en Broad Institute

The is dedicated to solving the world’s most challenging biomedical problems through the continuous development and investment in cutting edge technology and large-scale research projects that are both challenging and complex. In support of continually changing initiatives, the Process Development Associate I is committed to carrying out innovative, high-throughput lab processes and supporting the highest quality research to understand the impacts of genetic regulation on human health and disease. Process Development Associates I (PDA I) are responsible for processing samples through a high throughput clinical research laboratory and meeting production goals. PDAIs in this position will complete multi-step processes for cell expansion, banking, perturbations, screens and working to develop cellular models of disease and biological processes of interest to researchers. In addition to standard production processes, this position will require individuals to participate in continuous improvement solutions through appropriate change management procedures and troubleshooting processes as needed. The individual may be involved with the designing and executing of development, process improvement, or troubleshooting projects under direct guidance from the supervisor in support of platform goals and may be required to complete related training in JMP, Six Sigma, or other process improvement methods. Upon completion of these projects the individual is responsible for documenting and communicating results to others in the Platform during dedicated meetings. In addition, PDAs will assist with the general supervision of work of other laboratory personnel such as Process Development Technicians and Accessioning Technicians as required. REQUIREMENTSBS/BA degree in Biology or Chemistry. Please be prepared to provide a copy of the diploma and transcripts upon request.1+ years of relevant full time laboratory experience in this specialty subsequent to obtainingWorking, solid knowledge of basic aseptic / cell culture laboratory techniques required.Strong analytical skills, problem solving ability, and innovation aptitude required.Recent (within the last year) laboratory experience with the use of standard cell lab equipment such as pipettes, centrifuges, biosafety cabinets, microscopes, gel electrophoresis required.Knowledge of high-throughput screening and automation and/or experience working in a high throughput production setting is desired, but not requiredExperience with genome editing tools including CRISPR targeting in various human cell types is preferred.Strong hands-on experience in molecular biology, genomics, and cellular biology (cell-based assays) is preferred.Familiarity with single cell sequencing methods preferred.Experience with iPSCs, cell line and/or primary cell culture preferred.JOB RESPONSIBILITIES:Maintain and optimize mammalian cell culture systems for screening experiments.Apply functional genomics techniques, including epigenomics, single-cell, transcriptomics, and CRISPR-based assays in human cells and tissuesFollow standard operating proceduresEach individual performs only those high complexity tests that are authorized by theLaboratory Director and require a degree of skill commensurate with the individual’s education, training, experience, and technical abilities.Tests will require the exercise of independent judgment and responsibility with minimal supervisor by the laboratory director or supervisorAdhere to the laboratory’s quality control policies, document all quality control activities, instrument and procedural calibrations and maintenance performed.Follow the laboratory's established policies and procedures whenever test systems are not within the laboratory’s established acceptable levels of performance.Be capable of identifying problems that may adversely affect test performance or reporting of test results. Correct the problems according to procedures or immediately notify the General Supervisor, Technical Supervisor, Clinical Consultant or Laboratory Director.Document all corrective actions taken when test systems deviate from the laboratory's established performance specifications.Review and monitor quality metrics and communicate results to others in the Platform during dedicated meetings as needed. Solicitar ahora