The Contract Research Associate will be responsible for assisting in the development and optimization of the production and purification of AAV therapies in Lexeo's NYC lab. The successful candidate will master the downstream purification process and become a driver of process innovation. The Contract Research Associate will have the opportunity to learn at a fast-paced startup company with multiple ongoing clinical trials for novel cardiac and neurodegenerative gene therapies. The Research Associate’s work will directly impact ongoing and future clinical trials.
Essential Duties and Responsibilities
Perform downstream purification process development and optimization for LEXEO’s industry leading gene therapy manufacturing process
Participate/collaborate closely with the analytical development team to evaluate gene therapy product characterization, critical quality attributes, and process performance parameters
Prepare manufacturing process data summaries, process descriptions, process reports, and technology transfer reports
Present process improvement work to the broader company and contribute to external presentations
Engage with external partners including CMO/manufacturing teams and analytical partners
Purify vector for internal pre-clinical studies
Assist with process planning and resourcing to ensure alignment with company timelines
Perform other duties as required
Qualifications
BS/MS or equivalent in biology, biochemistry, or other relevant life science
Hands on laboratory experience in biologics with an understanding of lab safety
An understanding of virus/viral vector properties and experience with the development of downstream or upstream processes for viral vectors/gene therapy products are highly desirable
Hands-on experience with AKTA chromatography and filtration systems is a plus
Understanding of the fundamentals of chromatography and/or membrane separations preferred
Prior experience with characterizing and troubleshooting bioprocessing methods
Strong verbal and written communication skills
Enthusiasm and curiosity for the science behind creating world class AAV therapies!
LEXEO Therapeutics is a New York City-based, clinical-stage gene therapy company focused on addressing some of the most devastating genetically defined cardiovascular and central nervous system diseases affecting both larger-rare and prevalent patient populations. LEXEO’s foundational science stems from partnerships and exclusive licenses with leading academic laboratories at Weill Cornell Medicine and the University of California, San Diego. LEXEO is advancing a deep and diverse pipeline of AAV-based gene therapy candidates in rare cardiovascular diseases and APOE4-associated Alzheimer’s disease and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing, and commercialization.
Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
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